I use the Bad Behavior plugin to take the proverbial legs out from under comment spammers and then have Akismet to clean up the rest. However, even a few days before my upgrade to WordPress 2.5, my login stopped working. The only way to get into my Dashboard is to disable the plugin remotely.
There is this fix to allow the new Flash-based upload system to work with Bad Behavior enabled, but I cannot find a similar workaround for my login issue. With the plugin disabled, I have realized just how much "attention" my site gets from spammers, as I regularly clean out upwards of 30 comments twice a day. With that in mind, if you have left a comment in the last few days, e-mail me or simply post it again. I will try to catch it this time.